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Selected scientific articles

Pub Med web site lets you search all these articles citations and abstracts: www.ncbi.nlm.nih.gov/pubmed

 

Metabolic subtypes of nonalcoholic fatty liver disease patients exhibit distinctive cardiovascular risk profiles

Martinez-Arranz I, et al.

Hepatology 2022, in press

 

 

A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH

Fraser DA, et al.

Journal of Hepatology 2022;76(4):800-814

 

 

Inhibition of carnitine palmitoyl-transferase 1A in hepatic stellate cells protects against fibrosis

Fondevila MF, et al.

Journal of Hepatology 2022, in press

 

 

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Masoodi M, et al.

Nat Rev Gastroenterol Hepatol 2021;18(12):835-856

 

 

Identification of a metabolic, transcriptomic and molecular signature of PNPLA3-mediated acceleration of steatohepatitis

Banini BA, et al.

Hepatology 2021;73(4):1290-1306

 

 

RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease

Afonso MB, et al.

Gut 2021;70(12):2359-72

 

 

The L-α-lysophosphatidylinositol/GPR55 System Induces the Development of Non-Alcoholic Steatosis and Steatohepatitis

Fondevila MF, et al.

Hepatology 2021;73(2):606-24

 

 

The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma.

Lewinska M, et al.

EBioMedicine 2021;73:103661

 

 

Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Marques V, et al.

Fronteirs in Medicine 2021;8:683250.

 

 

Endogenous cortisol excess confers a unique lipid signature and metabolic network

Vega-Beyhart A, et al.

J Mol Med (Berl). 2021;99(8):1085-99.

 

 

Utility of Metabolomic Biomarkers to Identify Nonalcoholic Fatty Liver Disease in Liver Transplant Recipients

Mowry CJ, et al.

Liver Transplantation 2021;7(12):e784.

 

 

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Simon J, et al.

Cell Metab. 2020;31(3):605-22

 

 

Agonist of RORA Attenuates Non-Alcoholic Fatty Liver Progression in Mice via Upregulation of microRNA 122

Chai C, et al.

Gastroenterology 2020;159(3):999-1014

 

 

Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative

Stokman G, et al.

Liver International 2020;40(11):2860-76

 

 

The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

Kumar DP, et al.

Science Reports 2020;10(1),9330.

 

 

Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

Fernández-Ramos, et al.

World J Gastroenterol 2020;26(34):5101-17

 

 

Icosabutate exerts beneficial effects upon insulin sensitivity, hepatic inflammation, lipotoxicity and fibrosis in mice

van den Hoek AM, et al.

Hepatol Commun. 2020;4(2):193-207

 

 

Pilot Multi-Omic Analysis of Human Bile From Benign and Malignant Biliary Strictures: A Machine-Learning Approach

Urman JM, et al.

Cancers 2020;12(6):E1644

 

 

A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

Macias RIR, et al.

Cancers 2020;12(6):E1433

 

 

Topical treatment with sphingolipids and glycosaminoglycans for canine atopic dermatitis

Marsella R, et al.

BMC Vet Res. 2020;16(1):92

 

 

Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer

Clos-García M, et al.

Cancers 2020;12(5):1142

 

 

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl₄-Induced Liver Fibrosis

Mercado-Gómez M, et al.

Int. J. Mol. Sci. 2020;21(23), 9043

 

 

The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles

Matorras R, et al.

JARG 2020;37(2):385-94

 

 

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease

Mato JM, et al.

World J Gastroenterol. 2019;25(24):3009-20

 

 

Using metabolomics to develop precision medicine strategies to treat nonalcoholic steatohepatitis

Iruarrizaga-Lejarreta M, et al.

Expert review of precision medicine and drug development 2019;4(5):283-97

 

 

Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma and primary sclerosing cholangitis

Banales JM, et al.

Hepatology 2019;70(2):547-62

 

 

Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis

Michelena J, et al.

Ann Hepatol. 2019;18(1):144-54

 

 

Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis

Reverter E, et al.

Liver Int. 2019;39(4):705-13

 

 

A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins

Salto R, et al.

Nutrients 2019;11(4):844

 

 

Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models

Royo F, et al.

J Extracell Vesicles. 2019;8(1),1575678

 

 

Metabolomic-based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Mayo R, et al.

Hepatol Commun. 2018;2(7):807-20

 

 

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

Chalasani N, et al.

Aliment Pharmacol Ther. 2018;47(12):1639-51

 

 

Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice

Morrison MC, et al.

Hepatol Commun 2018;2(12):1513-32

 

 

Use of a Metabolomic Approach to Non-invasively Diagnose Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Bril F, et al.

Diabetes Obes Metab. 2018;20(7):1702-9

 

 

Feeding a slowly digestible carbohydrate diet during pregnancy of insulin-resistant rats prevents the excess of adipogenesis in their offspring

Martin MJ, et al.

Journal of Nutritional Biochemistry 2018;61:183-96

 

 

Targeted UPLC-MS Metabolic Analysis of Human Faeces Reveals Novel Low-Invasive Candidate Markers for Colorectal Cancer

Cubiella J, et al.

Cancers 2018;10(9):300; doi:10.3390/cancers10090300

 

 

Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Clos-García M, et al.

J Extracell Vesicles. 2018;7(1):1470442

 

 

The fatty acids of sphingomyelins and ceramides in mammalian tissues and cultured cells: biophysical and physiological implications.

Manni MM, et al.

Chem Phys Lipids. 2018; 217:29-34

 

 

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

Alonso C, et al.

Gastroenterology 2017;152(6):1449-61

 

 

A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients

Cano A, et al.

Sci Rep. 2017;5;7:10497

 

 

Role of Aramchol in steatohepatitis and fibrosis in mice

Iruarrizaga-Lejarreta M, et al.

Hepatol Commun. 2017;1:911-927

 

 

Effects of glucocorticoids on stratum corneum lipids and function in human skin-A detailed lipidomic analysis

Røpke MA, et al.

J Dermatol Sci. 2017;88:330-8

 

 

Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma

Arbelaiz A, et al.

Hepatology. 2017;66:1125-1143

 

 

Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.

Manni M, et al.

Chem Phys Lipids. 2017;203:54-70

 

 

Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes

Royo F, et al.

Eur J Pharm Sci. 2017;98:51-57

 

 

Metabolomic signatures associated with disease severity in multiple sclerosis

Villoslada P, et al.

Neurology: Neuroimmunology & Neuroinflammation 2017;4(2):e321

 

 

Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension

Seijó S, et al.

Liver Int. 2016;36(7):1051-8

 

 

Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum 1H-NMR Spectroscopy

Embade N, et al.

PLoS One 2016;11(5):e0155094

 

 

Enhancing metabolomics research through data mining

Martinez-Arranz, I et al.

J Proteomics 2015;127(B):275-88

 

 

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

Barbier-Torres L, et al.

Oncotarget 2015;6(4):2509-23

 

 

Lipids that determine detergent resistance of MDCK cell membrane fractions.

Manni MM, et al.

Chemistry and Physics of Lipids 2015;191:68-74

 

 

The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension

De los Santos, et al.

PLoS One 2015;10(11):e0142724

 

 

Deciphering non-alcoholic fatty liver disease through metabolomics

Cano A and Alonso C

Biochem Soc Trans. 2014;42(5):1447-52

 

 

High-melting lipid mixtures and the origin of detergent-resistant membranes studied with temperature-solubilization diagrams

Sot J, et al.

Biophysical Journal 2014;107(12):2828-37.

 

 

Nonalcoholic fatty liver disease

Alonso C and Mato JM

Chapter in: Global Metabolic Profiling: Clinical Applications
eBook ISBN: 978-1-909453-61-6 (Future Science Ltd) 2014

 

 

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

Martínez-Uña M, et al.

Hepatology 2013; 58(4):1296-305

 

 

Obesity-dependent metabolic signatures associated with nonalcoholic Fatty liver disease progression

Barr J, et al.

Journal of Proteome Research 2012;11(4),2521-32

 

 

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.

Vazquez-Chantada M, et al.

Hepatology 2013;57(2):505-14

 

 

Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension

Seijo S, et al.

The American Journal of Gastroenterology 2013;108(6):926-32

 

 

Effect of vitrification on human oocytes: a metabolic profiling study

Dominguez F, et al.

Fertility and Sterility 2013,99(2):565-72

 

 

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity

González E, et al.

Metabolomics 2012;8(6):997-1011

 

 

Liquid Chromatography-Mass Spectrometry (LC/MS)-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of non-alcoholic fatty liver disease

Barr J, et al.

Journal of Proteome Research 2010;9(9):4501-12

 

 

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