News > Metabomeeting 2014

Events

Metabomeeting 2014

 

Organized by the Metabolic Profiling Forum (MPF) and SELECTBIO

 

When: 10-12 September 2014

 

Where: The Royal Institution, London

 

Attendees from OWL: Dr. Cristina Alonso and Dr. Ainara Cano

 

Talk title:  A Metabolomic Signature Linked to Liver Fibrosis Progression Rate in the Serum of Transplanted Hepatitis C Patients

 

Speaker: Dr. Ainara Cano

 

Date of slot: Friday, 12 September, 15:00

 

Abstract

 

Biopsy is currently the gold standard for assessing the degree of hepatic fibrosis during hepatitis C virus infection (HCV) after liver transplantation. Therefore, a cheaper, faster and safer non-invasive diagnosis of the different stages of liver fibrosis will improve patient´s quality of life facilitating the efficient use of antiviral treatments. 200 HCV-infected patients were biopsied and classified into five categories of fibrosis one year after transplantation. These categories ranged from grade 0 (no fibrosis) to grade 4 (cirrhosis). Patients with grades 0 and 1 (n=131) were categorized as "slow fibrosers" and with grades 2, 3 and 4 (n=69) as “fast fibrosers”. Methanol and chloroform/methanol serum extracts were analyzed by reverse UPLC-MS. Approximately, 500 metabolites classified as amino acids, fatty acyls, glycerolipids, glycerophospholipids, sphingolipids and sterol lipids were semi-quantified in order to generate high accuracy predictive models. A metabolomic signature linked to liver fibrosis progression rate has been tracked down. Hence, fibrosis evolution reveals an increase in taurine and glycine-conjugated bile acid species, triacylglycerols and monounsaturated and polyunsaturated fatty acids in fast fibrosers when compared to slow fibrosers. In contrast, cholesteryl esters and the ratio branched-chain amino acids/aromatic amino acids decrease in this group.

 

We invite you to know our newest findings…

http://selectbiosciences.com/conferences/index.aspx?conf=meta2014

OWL is a trading name of
ONE WAY LIVER, S.L
Parque Tecnológico de Bizkaia
Edificio 502 - Planta 0
48160 Derio - Bizkaia - Spain
Phone:
+34 94 431 85 40

With this web OWL intends to provide users with information to better understand their health and their diagnosed illnesses. You should consult with a
qualified physician for diagnosis and for answers to your personal questions/circunstances.
Last update: 11/29/2021

With the collaboration of: