OWL > Management team > José María Mato de la Paz, PhD

Scientific Advisory Board

José María Mato de la Paz, PhD

Dr. José M Mato, professor and general director of the Center for Cooperative Research in Biosciences, CIC bioGUNE, in the Basque Country, received his Ph.D. degree from Leiden University (the Netherlands) and spent a year as a guest investigator conducting research in methionine metabolism in leukocyte chemotaxis at NIH, and then another year-long visit at the University of Pennsylvania.

He worked as a researcher at Jiménez Díaz Foundation (Madrid) .

In 1988 he became professor and director of the Institute of Biomedical Research of the Spanish Scientific Research Council (CSIC), the largest Spanish scientific research organization; and in 1992 he was appointed president of the CSIC.

Before establishing in the Basque Country, he was professor of medicine of the University of Navarra.

Dr. Mato has received a large number of prizes (Kok award, Morgagni Medal, Lennox K Blacky prize), and in 2004 he received the National Research Prize in Medicine, the highest recognition in science given by the Spanish state.

Dr. Mato’s research interests focus on fatty liver disease, hepatic regeneration and liver cancer, as well as the study of the role of S-adenosylmethionine (SAMe) in liver health and injury. Recent work by Dr. Mato’s group has uncovered a noncanonical LKB1/AMPK/eNOS cascade regulated by hepatocyte growth factor (HGF) and SAMe that functions as a critical determinant of hepatocyte proliferation during liver regeneration after partial hepatectomy and that is altered in animal models of hepatocarcinogenesis.


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