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Todos los artículos científicos de los que son autores los investigadores de OWL se pueden consultar a través de la página Web del servicio PubMed del National Center for Biotechnology Information: www.ncbi.nlm.nih.gov/pubmed


The L-α-lysophosphatidylinositol/GPR55 System Induces the Development of Non-Alcoholic Steatosis and Steatohepatitis

Fondevila MF, et al.

Hepatology 2020 (in press)



Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Simon J, et al.

Cell Metab. 2020;31(3):605-622



Agonist of RORA Attenuates Non-Alcoholic Fatty Liver Progression in Mice via Upregulation of microRNA 122

Chai C, et al.

Gastroenterology 2020 (in press)



Icosabutate exerts beneficial effects upon insulin sensitivity, hepatic inflammation, lipotoxicity and fibrosis in mice

van den Hoek AM, et al.

Hepatol Commun. 2020;4(2):193-207



The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

Kumar DP, et al.

Science Reports 2020;10(1),9330.



Pilot Multi-Omic Analysis of Human Bile From Benign and Malignant Biliary Strictures: A Machine-Learning Approach

Urman JM, et al.

Cancers 2020;12(6):E1644



A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

Macias RIR, et al.

Cancers 2020;12(6):E1433



Topical treatment with sphingolipids and glycosaminoglycans for canine atopic dermatitis

Marsella R, et al.

BMC Vet Res. 2020;16(1):92



Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer

Clos-García M, et al.

Cancers 2020;12(5):1142



The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles

Matorras R, et al.

JARG 2020;37(2):385-94



Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease

Mato JM, et al.

World J Gastroenterol. 2019;25(24):3009-20.



Using metabolomics to develop precision medicine strategies to treat nonalcoholic steatohepatitis

Iruarrizaga-Lejarreta M, et al.

Expert review of precision medicine and drug development 2019;4(5), 283-97



Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma and primary sclerosing cholangitis

Banales JM, et al.

Hepatology 2019;70(2):547-62.



Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis

Michelena J, et al.

Ann Hepatol. 2019;18(1):144-54



Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis

Reverter E, et al.

Liver Int. 2019;39(4):705-13



A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins

Salto R, et al.

Nutrients 2019;11(4):844



Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models

Royo F, et al.

J Extracell Vesicles. 2019;8(1),1575678



Metabolomic-based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Mayo R, et al.

Hepatol Commun. 2018;2(7):807-20



Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

Chalasani N, et al.

Aliment Pharmacol Ther. 2018;47(12):1639-51



Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice

Morrison MC, et al.

Hepatol Commun 2018;2(12):1513-32



Use of a Metabolomic Approach to Non-invasively Diagnose Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Bril F, et al.

Diabetes Obes Metab. 2018;20(7):1702-9



Feeding a slowly digestible carbohydrate diet during pregnancy of insulin-resistant rats prevents the excess of adipogenesis in their offspring

Martin MJ, et al.

Journal of Nutritional Biochemistry 2018;61:183-96



Targeted UPLC-MS Metabolic Analysis of Human Faeces Reveals Novel Low-Invasive Candidate Markers for Colorectal Cancer

Cubiella J, et al.

Cancers 2018;10(9):300; doi:10.3390/cancers10090300



Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Clos-García M, et al.

J Extracell Vesicles. 2018;7(1):1470442



The fatty acids of sphingomyelins and ceramides in mammalian tissues and cultured cells: biophysical and physiological implications.

Manni MM, et al.

Chem Phys Lipids. 2018; 217:29-34



Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

Alonso C, et al.

Gastroenterology 2017;152(6):1449-61



A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients

Cano A, et al.

Sci Rep. 2017;5;7:10497



Role of Aramchol in steatohepatitis and fibrosis in mice

Iruarrizaga-Lejarreta M, et al.

Hepatol Commun. 2017;1:911-927



Effects of glucocorticoids on stratum corneum lipids and function in human skin-A detailed lipidomic analysis

Røpke MA, et al.

J Dermatol Sci. 2017;88:330-8



Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma.

Arbelaiz A, et al.

Hepatology. 2017;66:1125-1143



Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes

Royo F, et al.

Eur J Pharm Sci. 2017;98:51-57



Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.

Manni M, et al.

Chem Phys Lipids. 2017;203:54-70



Metabolomic signatures associated with disease severity in multiple sclerosis

Villoslada P, et al.

Neurology: Neuroimmunology & Neuroinflammation 2017;4(2):e321



Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension

Seijó S, et al.

Liver Int. 2016;36(7):1051-8



Metabolic Characterization of Advanced Liver Fibrosis in HCV Patients as Studied by Serum 1H-NMR Spectroscopy

Embade N, et al.

PLoS One 2016;11(5):e0155094



Enhancing metabolomics research through data mining

Martinez-Arranz, I et al.

J Proteomics 2015;127(B):275-88



Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

Barbier-Torres L, et al.

Oncotarget 2015;6(4):2509-23



Lipids that determine detergent resistance of MDCK cell membrane fractions.

Manni MM, et al.

Chemistry and Physics of Lipids 2015;191:68-74



The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension

De los Santos, et al.

PLoS One 2015;10(11):e0142724



Deciphering non-alcoholic fatty liver disease through metabolomics

Cano A and Alonso C

Biochem Soc Trans. 2014;42(5):1447-52



High-melting lipid mixtures and the origin of detergent-resistant membranes studied with temperature-solubilization diagrams

Sot J, et al.

Biophysical Journal 2014;107(12):2828-37.



Nonalcoholic fatty liver disease

Alonso C and Mato JM

Chapter in: Global Metabolic Profiling: Clinical Applications
eBook ISBN: 978-1-909453-61-6 (Future Science Ltd) 2014



Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

Martínez-Uña M, et al.

Hepatology 2013; 58(4):1296-305



Obesity-dependent metabolic signatures associated with nonalcoholic Fatty liver disease progression.

Barr J, et al.

Journal of Proteome Research 2012;11(4),2521-32



Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.

Vazquez-Chantada M, et al.

Hepatology 2013;57(2):505-14



Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension.

Seijo S, et al.

The American Journal of Gastroenterology 2013;108(6):926-32



Effect of vitrification on human oocytes: a metabolic profiling study

Dominguez F, et al.

Fertility and Sterility 2013,99(2):565-72



Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity

González E, et al.

Metabolomics 2012;8(6):997-1011



Liquid Chromatography-Mass Spectrometry (LC/MS)-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of non-alcoholic fatty liver disease.

Barr J, et al.

Journal of Proteome Research 2010;9(9):4501-12





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